Long-term anticoagulation.3 The benefits of oral anticoagulants haveīeen clearly established in well-designed clinical trials.Ĭoumarin preparations are commonly used vitamin K antagonists inĬlinical practice.4 Warfarin, phenprocoumon and acenocoumarol, the Prevention of recurrent thromboembolic disorders.1 Vitamin K antagonistsĪre widely used oral anticoagulants worldwide.2,3 Vitamin K antagonistsĪct by inhibition of vitamin K epoxide reductase and are often used for Due to its economic advantage acenocoumarol may be suitable oral anticoagulant for long term use in countries like India.Īnticoagulant treatment is indicated for the treatment and It offers an advantage over warfarin in terms of better stability of anti-coagulant effect. Acenocoumarol is effective and safe in all age groups. Efficacy and safety of acenocoumarol has been evaluated in atrial fibrillation, cardiac valve replacement, after myocardial infarction, treatment of deep vein thrombosis, after major surgeries and after critical illness requiring prolonged hospitalization. Acenocoumarol is mono-coumarin derivative with racemic mixture of R (+) and S (-) enantiomers.
Vitamin K antagonists are commonly used oral anticoagulants worldwide. Anticoagulant treatment is required for the treatment and prevention of thromboembolic disorders.
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